Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006815)
Formula Reactant Sirolimus Product 46-OH-sirolimus
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Aliphatic hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006812 Sirolimus 11-OH-sirolimus Oxidation - Aliphatic hydroxylation Sirolimus [1]
MR006811 Sirolimus 12-OH-sirolimus Oxidation - Aliphatic hydroxylation Sirolimus [1]
MR006810 Sirolimus 16-O-Desmethylsirolimus Oxidation - O-dealkylation Sirolimus [1]
MR006814 Sirolimus 24-OH-sirolimus Oxidation - Aliphatic hydroxylation Sirolimus [1]
MR006813 Sirolimus 25-OH-sirolimus Oxidation - Aliphatic hydroxylation Sirolimus [1]
MR006809 Sirolimus 39-O-Desmethylsirolimus Oxidation - O-dealkylation Sirolimus [1]
MR006808 Sirolimus 41-O-demethylrapamycin Oxidation - 41-O-Demethylation Sirolimus [2]
MR002390 Sirolimus . Unclear Temsirolimus [3]
References
1 Cytochromes P450: a structure-based summary of biotransformations using representative substrates Drug Metab Rev. 2008;40(1):1-100. doi: 10.1080/03602530802309742.
2 FDA Approved Drug Products: RAPAMUNE (sirolimus) for oral use
3 American Society of Health System Pharmacists; AHFS Drug Information 2010. Bethesda, MD. (2010), p. 2511

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