Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006880)
Formula	Reduction
	Reactant	Entrectinib	Product	ENB477
	Reactant	Reactant Info	Product	Product Info
Metabolic Type	Reduction - Reduction

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR006879	Entrectinib	ENB547	Oxidation - N-dealkylation	Entrectinib	[1]
MR006875	Entrectinib	ENB577b	Oxidation - Hydrolyzationn	Entrectinib	[1]
MR006877	Entrectinib	ENB577c	Oxidation - N-oxidation	Entrectinib	[1]

References
1	LC-MS/MS reveals the formation of iminium and quinone methide reactive intermediates in entrectinib metabolism: In vivo and in vitro metabolic investigation

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