Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006879)
Formula
SVG example
N-dealkylation
Reactant Entrectinib Product ENB547
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006880 Entrectinib ENB477 Reduction - Reduction Entrectinib [1]
MR006875 Entrectinib ENB577b Oxidation - Hydrolyzationn Entrectinib [1]
MR006877 Entrectinib ENB577c Oxidation - N-oxidation Entrectinib [1]
References
1 LC-MS/MS reveals the formation of iminium and quinone methide reactive intermediates in entrectinib metabolism: In vivo and in vitro metabolic investigation

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