Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006875)
Formula
SVG example
Hydrolyzationn
Reactant Entrectinib Product ENB577b
Reactant Info Product Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006880 Entrectinib ENB477 Reduction - Reduction Entrectinib [1]
MR006879 Entrectinib ENB547 Oxidation - N-dealkylation Entrectinib [1]
MR006877 Entrectinib ENB577c Oxidation - N-oxidation Entrectinib [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006876 ENB577b ENB753 Conjugation - O-glucuronidation Entrectinib [1]
References
1 LC-MS/MS reveals the formation of iminium and quinone methide reactive intermediates in entrectinib metabolism: In vivo and in vitro metabolic investigation

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