Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006898)
Formula
SVG example
Oxidationn
Reactant Lopinavir Product Lopinavir Metabolite M-3/M-4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006900 Lopinavir Lopinavir Metabolite M-2 Oxidation - Oxidationn Lopinavir [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006899 Lopinavir Metabolite M-3/M-4 Lopinavir Metabolite M-1 Other reaction - Ketone formation Lopinavir [2]
References
1 In vitro metabolism of the HIV-1 protease inhibitor ABT-378: species comparison and metabolite identification
2 Synthesis and antiviral activities of the major metabolites of the HIV protease inhibitor ABT-378 (Lopinavir). Bioorg Med Chem Lett. 2001 Jun 4;11(11):1351-3.

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