| General Information of This Metabolic Reaction (MR) (ID:
MR006901) |
| Formula |
|
| Reactant |
Loratadine |
Product |
Desloratadine |
|
Reactant Info
|
Product Info
|
|
Metabolic Enzyme
|
Cytochrome P450 3A4 (CYP3A4)
|
DME Info
|
|
Cytochrome P450 2D6 (CYP2D6)
|
DME Info
|
|
Mephenytoin 4-hydroxylase (CYP2C19)
|
DME Info
|
|
Cytochrome P450 1A1 (CYP1A1)
|
DME Info
|
|
Metabolic Type
|
Oxidation
-
Oxidationn
|
|
|
|
|
|
|
|
| Other MR(s) Related to The Product of This MR |
|
Other MR(s) That Produce The Product of This MR
|
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| References |
| 1 |
CYP3A5*3 and MDR1 C3435T are influencing factors of inter-subject variability in rupatadine pharmacokinetics in healthy Chinese volunteers. Eur J Drug Metab Pharmacokinet. 2016 Apr;41(2):117-24.
|
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