Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006915)
Formula
UGT1A1 ...
SVG example
N-glucuronidation
Reactant Losartan potassium Product Losartan N2-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 1A10 (UGT1A10) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME Info
Metabolic Type Conjugation - N-glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006913 Losartan potassium Losartan Carboxaldehyde Oxidation - Oxidationn Losartan potassium [1]
MR006916 Losartan potassium Losartan carboxylic acid Oxidation - N-oxidation Losartan potassium [1]
References
1 Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814.

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