Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006913)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Losartan potassium Product Losartan Carboxaldehyde
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006916 Losartan potassium Losartan carboxylic acid Oxidation - N-oxidation Losartan potassium [1]
MR006915 Losartan potassium Losartan N2-glucuronide Conjugation - N-glucuronidation Losartan potassium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013896 Losartan E 3179 Unclear - Unclear Losartan [1]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013897 E 3179 E3174 Unclear - Unclear Losartan [1]
MR006914 Losartan Carboxaldehyde Losartan carboxylic acid Unclear Losartan potassium [2]
References
1 Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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