Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006916)
Formula
CYP3A4 ...
SVG example
N-oxidation
Reactant Losartan potassium Product Losartan carboxylic acid
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - N-oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006913 Losartan potassium Losartan Carboxaldehyde Oxidation - Oxidationn Losartan potassium [1]
MR006915 Losartan potassium Losartan N2-glucuronide Conjugation - N-glucuronidation Losartan potassium [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR013897 E 3179 E3174 Unclear - Unclear Losartan [1]
MR006914 Losartan Carboxaldehyde Losartan carboxylic acid Unclear Losartan potassium [2]
References
1 Clinical pharmacokinetics of losartan. Clin Pharmacokinet. 2005;44(8):797-814.
2 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.