Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006921)
Formula Reactant Lovastatin Product beta-hydroxy acid of lovastatin
Reactant Info Product Info
Metabolic Enzyme Serum paraoxonase/lactonase 3 (PON3) DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006923 beta-hydroxy acid of lovastatin 3''-Hydroxylovastatin Unclear Lovastatin [1]
MR006922 beta-hydroxy acid of lovastatin 6'-beta-Hydroxylovastatin Oxidation - Hydrolyzationn Lovastatin [2]
MR006924 beta-hydroxy acid of lovastatin 6'-Exomethylene lovastatin Reduction - Reduction Lovastatin [3]
References
1 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
2 Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.
3 Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb;27(2):173-9.

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