Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006923)
Formula Reactant beta-hydroxy acid of lovastatin Product 3''-Hydroxylovastatin
Reactant Info Product Info
Metabolic Enzyme Carboxylesterase (CES) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006921 Lovastatin beta-hydroxy acid of lovastatin Hydrolysis - Hydrolysis Lovastatin [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006922 beta-hydroxy acid of lovastatin 6'-beta-Hydroxylovastatin Oxidation - Hydrolyzationn Lovastatin [3]
MR006924 beta-hydroxy acid of lovastatin 6'-Exomethylene lovastatin Reduction - Reduction Lovastatin [4]
References
1 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
2 Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
3 Pharmacogenomics of statins: understanding susceptibility to adverse effects. Pharmgenomics Pers Med. 2016 Oct 3;9:97-106.
4 Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb;27(2):173-9.

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