Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006922)
Formula Reactant beta-hydroxy acid of lovastatin Product 6'-beta-Hydroxylovastatin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006921 Lovastatin beta-hydroxy acid of lovastatin Hydrolysis - Hydrolysis Lovastatin [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006923 beta-hydroxy acid of lovastatin 3''-Hydroxylovastatin Unclear Lovastatin [1]
MR006924 beta-hydroxy acid of lovastatin 6'-Exomethylene lovastatin Reduction - Reduction Lovastatin [3]
References
1 Paraoxonases-1, -2 and -3: what are their functions? Chem Biol Interact. 2016 Nov 25;259(Pt B):51-62.
2 Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities
3 Comparison of cytochrome P-450-dependent metabolism and drug interactions of the 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors lovastatin and pravastatin in the liver. Drug Metab Dispos. 1999 Feb;27(2):173-9.

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