Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR006991)
Formula
CYP2C9 ...
SVG example
3'-hydroxylation
Reactant VA-10872 Product 3'-Hydroxyhexobarbital
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - 3'-hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006996 VA-10872 Epoxy-hexobarbital Unclear VA-10872 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006995 3'-Hydroxyhexobarbital 3'-Hydroxyhexobarbital O-glucuronide Conjugation - Glucuronidation VA-10872 [1]
MR006992 3'-Hydroxyhexobarbital 3'-Oxohexobarbitall Oxidation - Oxidationn VA-10872 [1]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.

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