Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007117)
Formula Reactant Dihydrocodeine Product Dihydrocodeine-6-glucuronide
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 2B4 (UGT2B4) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007119 Dihydrocodeine DHNC Oxidation - N-demethylation Dihydrocodeine [1], [2]
MR007115 Dihydrocodeine Dihydromorphine Oxidation - O-demethylation Dihydrocodeine [3], [4]
MR007121 Dihydrocodeine Nordihydrocodeine Unclear Dihydrocodeine [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007118 Dihydrocodeine-6-glucuronide DHNCG Oxidation - N-demethylation Dihydrocodeine [1], [2]
References
1 Metabolism and pharmacokinetics of dihydrocodeine in dog
2 Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharm Drug Dispos. 2019 Nov;40(9):350-357.
3 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
4 Dihydrocodeine: safety concerns

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