Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007121)
Formula
SVG example
Reactant Dihydrocodeine Product Nordihydrocodeine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007119 Dihydrocodeine DHNC Oxidation - N-demethylation Dihydrocodeine [1], [2]
MR007117 Dihydrocodeine Dihydrocodeine-6-glucuronide Conjugation - Glucuronidation Dihydrocodeine [3], [2]
MR007115 Dihydrocodeine Dihydromorphine Oxidation - O-demethylation Dihydrocodeine [3], [4]
References
1 Metabolism and pharmacokinetics of dihydrocodeine in dog
2 Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharm Drug Dispos. 2019 Nov;40(9):350-357.
3 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
4 Dihydrocodeine: safety concerns

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