Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007119)
Formula
SVG example
N-demethylation
Reactant Dihydrocodeine Product DHNC
Reactant Info Product Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007117 Dihydrocodeine Dihydrocodeine-6-glucuronide Conjugation - Glucuronidation Dihydrocodeine [1], [2]
MR007115 Dihydrocodeine Dihydromorphine Oxidation - O-demethylation Dihydrocodeine [1], [3]
MR007121 Dihydrocodeine Nordihydrocodeine Unclear Dihydrocodeine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007120 DHNC DHNCG Conjugation - Glucuronidation Dihydrocodeine [4]
References
1 Pharmacokinetics of dihydrocodeine and its active metabolite after single and multiple oral dosing. Br J Clin Pharmacol. 1999 Sep;48(3):317-22.
2 Adult and infant pharmacokinetic profiling of dihydrocodeine using physiologically based pharmacokinetic modeling. Biopharm Drug Dispos. 2019 Nov;40(9):350-357.
3 Dihydrocodeine: safety concerns
4 Metabolism and pharmacokinetics of dihydrocodeine in dog

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