Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007190)
Formula
CYP3A4 ...
SVG example
Oxidationn
Reactant Flucloxacillin Product 5-hydroxymethyl-flucloxacillin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Oxidationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007192 Flucloxacillin Flucloxacillin penicilloic acids Hydrolysis - Hydrolysis Flucloxacillin [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007191 5-hydroxymethyl-flucloxacillin 5-hydroxymethyl-flucloxacillin penicilloic acids Hydrolysis - Hydrolysis Flucloxacillin [1]
References
1 Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A-catalysed hydroxylation by sulfaphenazole. Br J Pharmacol. 2019 Feb;176(3):466-477.

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