Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007208)
Formula
PTGS1 ...
SVG example
Cyclooxygenation
Reactant Arachidonic Acid Product Thromboxanes
Reactant Info Product Info
Metabolic Enzyme Prostaglandin G/H synthase 1 (COX-1) DME Info
Prostaglandin G/H synthase 2 (COX-2) DME Info
Metabolic Type Oxidation - Cyclooxygenation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007494 Arachidonic acid 19-HETE Other reaction - Omega-hydroxylation Arachidonic acid [1]
MR007493 Arachidonic acid 20-HETE Other reaction - Omega-hydroxylation Arachidonic acid [1]
MR007495 Arachidonic acid AA-CoA Unclear Arachidonic acid [2]
MR007489 Arachidonic acid EET Unclear Arachidonic acid [1]
MR007492 Arachidonic acid Leukotriens Unclear Arachidonic acid [1]
MR007491 Arachidonic acid Prostaglandin H2 Unclear Arachidonic acid [3], [1]
References
1 Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22.
2 Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism
3 Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics. 2007 Feb;17(2):145-60.

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