Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007489)
Formula
CYP2C8 ...
SVG example
Reactant Arachidonic acid Product EET
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2J2 (CYP2J2) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007494 Arachidonic acid 19-HETE Other reaction - Omega-hydroxylation Arachidonic acid [1]
MR007493 Arachidonic acid 20-HETE Other reaction - Omega-hydroxylation Arachidonic acid [1]
MR007495 Arachidonic acid AA-CoA Unclear Arachidonic acid [2]
MR007492 Arachidonic acid Leukotriens Unclear Arachidonic acid [1]
MR007491 Arachidonic acid Prostaglandin H2 Unclear Arachidonic acid [3], [1]
MR007208 Arachidonic Acid Thromboxanes Oxidation - Cyclooxygenation Gamma-linolenic acid [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007490 EET 11,12-DHET Unclear Arachidonic acid [1]
References
1 Role of cytochrome P450 enzymes in the bioactivation of polyunsaturated fatty acids. Biochim Biophys Acta. 2011 Jan;1814(1):210-22.
2 Role of acyl-CoA synthetase ACSL4 in arachidonic acid metabolism
3 Identification and functional characterization of polymorphisms in human cyclooxygenase-1 (PTGS1). Pharmacogenet Genomics. 2007 Feb;17(2):145-60.
4 Gamma-linolenic acid, Dihommo-gamma linolenic, Eicosanoids and Inflammatory Processes

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