Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007223)
Formula
CYP2C9 ...
SVG example
Hydrolyzationn
Reactant Gliclazide Product Methylhydroxygliclazide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007227 Gliclazide 6-OH-gliclazide Oxidation - Hydrolyzationn Gliclazide [1], [2]
MR007225 Gliclazide 7-OH-gliclazide Oxidation - Hydrolyzationn Gliclazide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007224 Methylhydroxygliclazide Carboxygliclazide Oxidation - Oxidationn Gliclazide [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 The metabolism of gliclazide in man

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