Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007227)
Formula Reactant Gliclazide Product 6-OH-gliclazide
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Hydrolyzationn
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007225 Gliclazide 7-OH-gliclazide Oxidation - Hydrolyzationn Gliclazide [1], [2]
MR007223 Gliclazide Methylhydroxygliclazide Oxidation - Hydrolyzationn Gliclazide [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007228 6-OH-gliclazide 6-OH-gliclazide glucuronide Conjugation - Glucuronidation Gliclazide [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 The metabolism of gliclazide in man

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