Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007262)
Formula Reactant ARQ-501 Product Catechol intermediate
Reactant Info Product Info
Metabolic Enzyme Quinone reductase 1 (NQO1) DME Info
Metabolic Type Reduction - Reduction
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007271 ARQ-501 ARQ-501 M6 Unclear ARQ-501 [1]
MR007266 ARQ-501 Unclear Oxidation - Oxidationn ARQ-501 [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007263 Catechol intermediate ARQ-501 M1 Conjugation - Monoglucuronidation ARQ-501 [1]
MR007264 Catechol intermediate ARQ-501 M2 Conjugation - Monoglucuronidation ARQ-501 [1]
MR007265 Catechol intermediate ARQ-501 M5 Conjugation - Glucuronidation ARQ-501 [1]
References
1 Metabolic profile, enzyme kinetics, and reaction phenotyping of -lapachone metabolism in human liver and intestine in vitro

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