Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007264)
Formula Reactant Catechol intermediate Product ARQ-501 M2
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A7 (UGT1A7) DME Info
UDP-glucuronosyltransferase 1A8 (UGT1A8) DME Info
UDP-glucuronosyltransferase 1A9 (UGT1A9) DME Info
Metabolic Type Conjugation - Monoglucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007262 ARQ-501 Catechol intermediate Reduction - Reduction ARQ-501 [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007263 Catechol intermediate ARQ-501 M1 Conjugation - Monoglucuronidation ARQ-501 [1]
MR007265 Catechol intermediate ARQ-501 M5 Conjugation - Glucuronidation ARQ-501 [1]
References
1 Metabolic profile, enzyme kinetics, and reaction phenotyping of -lapachone metabolism in human liver and intestine in vitro

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