Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007297)
Formula Reactant Paracetamol Product Glucuronidation of paracetamol
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A1 (UGT1A1) DME Info
Metabolic Type Conjugation - Glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007295 BCP-13498 Paracetamol Unclear BCP-13498 [1]
MR005147 4-aminophenol N-acetyl-4-Aminophenol Conjugation - Acetylation Phenazopyridine [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007296 Paracetamol N-acetil-p-benzoquinone imine Unclear BCP-13498 [5]
MR007298 Paracetamol Unclear Unclear BCP-13498 [6]
MR014085 Paracetamol Unclear Unclear BCP-13498 [7]
References
1 DrugBank(Pharmacology-Metabolism):BCP-13498
2 Metabolism and disposition of phenazopyridine in rat
3 The metabolism and excretion of phenazopyridine hydrochloride in animals and man
4 Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs
5 Involvement of human cytochrome P450 2D6 in the bioactivation of acetaminophen. Drug Metab Dispos. 2000 Dec;28(12):1397-400.
6 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
7 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.