Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007296)
Formula Reactant Paracetamol Product N-acetil-p-benzoquinone imine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2E1 (CYP2E1) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007295 BCP-13498 Paracetamol Unclear BCP-13498 [1]
MR005147 4-aminophenol N-acetyl-4-Aminophenol Conjugation - Acetylation Phenazopyridine [2], [3], [4]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007297 Paracetamol Glucuronidation of paracetamol Conjugation - Glucuronidation BCP-13498 [5]
MR007298 Paracetamol Unclear Unclear BCP-13498 [6]
MR014085 Paracetamol Unclear Unclear BCP-13498 [7]
References
1 DrugBank(Pharmacology-Metabolism):BCP-13498
2 Metabolism and disposition of phenazopyridine in rat
3 The metabolism and excretion of phenazopyridine hydrochloride in animals and man
4 Excretion of phenazopyridine and its metabolites in the urine of humans, rats, mice, and guinea pigs
5 Paracetamol glucuronidation by recombinant rat and human phenol UDP-glucuronosyltransferases. Biochem Pharmacol. 1993 May 5;45(9):1809-14.
6 Human UGT1A6 pharmacogenetics: identification of a novel SNP, characterization of allele frequencies and functional analysis of recombinant allozymes in human liver tissue and in cultured cells. Pharmacogenetics. 2004 Aug;14(8):487-99.
7 Polymorphic expression of UGT1A9 is associated with variable acetaminophen glucuronidation in neonates: a population pharmacokinetic and pharmacogenetic study. Clin Pharmacokinet. 2018 Oct;57(10):1325-1336.

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