Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008109)
Formula
SVG example
Hydrolysis
Reactant Penicillin V Product Penicilloic acid
Reactant Info Product Info
Metabolic Enzyme #NAME? DME Info
Metabolic Type Hydrolysis - Hydrolysis
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008112 Penicillin V 6-aminopenicillanic acid Unclear - Unclear Penicillin V [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008139 Dicloxacillin Penicilloic acid Hydrolysis - Hydrolysis Dicloxacillin [2]
MR008090 Mezlocillin Penicilloic acid Hydrolysis - Hydrolysis Mezlocillin [3]
MR008131 Penicillin Penicilloic acid Unclear - Unclear Penicillin [4]
MR001970 Penicillin G Penicilloic acid Unclear Penicillin G [5]
MR008099 Penicillin G Sodium Penicilloic acid Oxidation - Oxidation Penicillin G Sodium [6]
MR013678 Penicillin V Potassium Penicilloic acid Hydrolysis - Hydrolysis Penicillin V Potassium [7], [8]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR001969 Penicilloic acid 8-hydroxypenillic acid Oxidation - Hydroxylation Penicillin G [5]
MR008102 Penicilloic acid Penicillin G Sodium metabolite M5 Oxidation - Hydroxylation Penicillin G Sodium [6]
MR008101 Penicilloic acid Penicillin G Sodium metabolite M6 Conjugation - Glucuronidation Penicillin G Sodium [6]
MR008110 Penicilloic acid Penicillin V metabolite 1 Unclear - Unclear Penicillin V [8]
MR008111 Penicilloic acid Penicillin V metabolite 3 Unclear - Unclear Penicillin V [8]
MR013679 Penicilloic acid Penicillin V Potassium metabolite 1 Unclear Penicillin V Potassium [8]
MR013680 Penicilloic acid Penicillin V Potassium3 Unclear Penicillin V Potassium [8]
MR008100 Penicilloic acid Penilloate Reduction - Decarboxylation Penicillin G Sodium [6]
MR008091 Penicilloic acid Penilloic acid Unclear - Unclear Mezlocillin [3]
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References
1 Specificity of penicillin acylase of Fusarium and of Penicillium chrysogenum
2 PubChem:Dicloxacillin
3 High-performance liquid chromatography analysis of mezlocillin, piperacillin, their degradation products, and of ioxitalamic acid in plasma and urine of healthy volunteers
4 Metabolism of penicillins to penicilloic acids and 6-aminopenicillanic acid in man and its significance in assessing penicillin absorption
5 McEvoy, G.K. (ed.). American Hospital Formulary Service - Drug Information 1999. Bethesda, MD:American Society of Health-System Pharmacists, Inc. 1999 (Plus Supplements)., p. 1760
6 Identification of new minor metabolites of penicillin G in human serum by multiple-stage tandem mass spectrometry
7 Enzyme-catalyzed biodegradation of penicillin fermentation residues by -lactamase OtLac from Ochrobactrum tritici
8 Isolation and Characterization of Ochrobactrum tritici for Penicillin V Potassium Degradation

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