Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008145)
Formula
SVG example
Unclear
Reactant Phytonadione Product Quinone
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008149 Phytonadione Hydroxyvitamin K1 Oxidation - Hydroxylation Phytonadione [1], [2], [3], [4], [5]
MR008151 Phytonadione Vitamin K 5 Carbon Metabolite Unclear - Unclear Phytonadione [1], [2], [3], [4], [5]
MR008152 Phytonadione Vitamin K 7 Carbon Metabolite Unclear - Unclear Phytonadione [1], [2], [3], [4], [5]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007626 Pyrogallol Quinone Unclear Pyrogallol [6]
MR007418 CP-125611 Quinone Unclear CP-122721 [7], [8]
References
1 Metabolism of vitamin K1 (phylloquinone) in man
2 Vitamin K nutrition, metabolism, and requirements: current concepts and future research
3 Dietary reference values for vitamin K
4 Preparative isolation and characterization of the urinary aglycones of vitamin K1 (phylloquinone in man
5 Cytochrome P450-dependent catabolism of vitamin K: -hydroxylation catalyzed by human CYP4F2 and CYP4F11
6 Metabolism of pyrogallol to purpurogallin by human erythrocytic hemoglobin
7 In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49.
8 Metabolism, pharmacokinetics, and excretion of the substance P receptor antagonist CP-122,721 in humans: structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography-tandem mass spectrometry and NMR spectroscopy

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