Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR007418)
Formula
CYP1A2 ...
SVG example
Reactant CP-125611 Product Quinone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 3A (CYP3A) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007417 CP-122721 CP-125611 Oxidation - O-demethylation CP-122721 [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR007421 CP-125611 CP-919230 Oxidation - N-dealkylation CP-122721 [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008145 Phytonadione Quinone Unclear - Unclear Phytonadione [3]
MR007626 Pyrogallol Quinone Unclear Pyrogallol [4]
References
1 In vitro metabolism of CP-122,721 ((2S,3S)-2-phenyl-3-[(5-trifluoromethoxy-2-methoxy)benzylamino]piperidine), a non-peptide antagonist of the substance P receptor. Drug Metab Pharmacokinet. 2007 Oct;22(5):336-49.
2 Metabolism, pharmacokinetics, and excretion of the substance P receptor antagonist CP-122,721 in humans: structural characterization of the novel major circulating metabolite 5-trifluoromethoxy salicylic acid by high-performance liquid chromatography-tandem mass spectrometry and NMR spectroscopy
3 Recent trends in the metabolism and cell biology of vitamin K with special reference to vitamin K cycling and MK-4 biosynthesis
4 Metabolism of pyrogallol to purpurogallin by human erythrocytic hemoglobin

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