Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008292)
Formula
UGT1A3 ...
SVG example
N-carbamoyl glucuronidation
Reactant BIIB074 Product BIIB074 metabolite M13
Reactant Info Product Info
Metabolic Enzyme UDP-glucuronosyltransferase 1A3 (UGT1A3) DME Info
UDP-glucuronosyltransferase 2B7 (UGT2B7) DME Info
Metabolic Type Conjugation - N-carbamoyl glucuronidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008293 BIIB074 BIIB074 metabolite M10 Unclear - Unclear BIIB074 [1]
MR008290 BIIB074 BIIB074 metabolite M14 Hydrolysis - Amide hydrolysis BIIB074 [1]
References
1 Evaluation of the Pharmacokinetic Interaction Between the Voltage- and Use-Dependent Nav1.7 Channel Blocker Vixotrigine and Carbamazepine in Healthy Volunteers

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