Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008652)
Formula Reactant Sunitinib malate Product Sun-SG
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008644 Sunitinib malate SU12662 Oxidation - Deethylation Sunitinib malate [1]
MR008645 Sunitinib malate Sunitinib malate Metabolite M11 Unclear - Unclear Sunitinib malate [2]
MR008650 Sunitinib malate Sunitinib malate Metabolite M2E Unclear - Unclear Sunitinib malate [2]
MR008648 Sunitinib malate Sunitinib malate Metabolite M2F Unclear - Unclear Sunitinib malate [2]
MR008649 Sunitinib malate Sunitinib malate Metabolite M3 Oxidation - Bis-deethylation Sunitinib malate [2]
MR008651 Sunitinib malate Sunitinib malate Metabolite M4E Unclear - Unclear Sunitinib malate [2]
MR008647 Sunitinib malate Sunitinib malate Metabolite M8 Reduction - Reduction Sunitinib malate [2], [3]
MR008646 Sunitinib malate Sunitinib malate Metabolite M9 Unclear - Unclear Sunitinib malate [2]
References
1 Sunitinib malate for the treatment of metastatic renal cell carcinoma and gastrointestinal stromal tumors
2 Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans
3 Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib

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