Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008644)
Formula
SVG example
Deethylation
Reactant Sunitinib malate Product SU12662
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - Deethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008652 Sunitinib malate Sun-SG Unclear - Unclear Sunitinib malate [1]
MR008645 Sunitinib malate Sunitinib malate Metabolite M11 Unclear - Unclear Sunitinib malate [1]
MR008650 Sunitinib malate Sunitinib malate Metabolite M2E Unclear - Unclear Sunitinib malate [1]
MR008648 Sunitinib malate Sunitinib malate Metabolite M2F Unclear - Unclear Sunitinib malate [1]
MR008649 Sunitinib malate Sunitinib malate Metabolite M3 Oxidation - Bis-deethylation Sunitinib malate [1]
MR008651 Sunitinib malate Sunitinib malate Metabolite M4E Unclear - Unclear Sunitinib malate [1]
MR008647 Sunitinib malate Sunitinib malate Metabolite M8 Reduction - Reduction Sunitinib malate [1], [2]
MR008646 Sunitinib malate Sunitinib malate Metabolite M9 Unclear - Unclear Sunitinib malate [1]
References
1 Pharmacokinetics, distribution, and metabolism of [14C]sunitinib in rats, monkeys, and humans
2 Cytochromes P450 1A2 and 3A4 Catalyze the Metabolic Activation of Sunitinib

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