Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR008682)
Formula
SVG example
Unclear
Reactant Dihydroqinghaosu (DQHS) Product Deoxydihydro-artemisinin
Reactant Info Product Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008681 Arteether Dihydroqinghaosu (DQHS) Oxidation - Deethylation Arteether [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000302 Artemether Deoxydihydro-artemisinin Unclear Artemether [3]
MR000315 2,3-dikeogulonic acid Deoxydihydro-artemisinin Unclear Ascorbic acid [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008683 Deoxydihydro-artemisinin Arteether Metabolite M1 Oxidation - Hydroxylation Arteether [2]
References
1 Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450
2 Synthesis, characterization, and antimalarial activity of the glucuronides of the hydroxylated metabolites of arteether
3 DrugBank(Pharmacology-Metabolism)Artemether
4 Ascorbic acid intake and oxalate synthesis Urolithiasis. 2016 Aug;44(4):289-97. doi: 10.1007/s00240-016-0868-7.

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