Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR000302)
Formula
SVG example
Reactant Artemether Product Deoxydihydro-artemisinin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR000299 Artemether 9,10-dihydrodeoxy-artemsinin Unclear Artemether [1]
MR000300 Artemether Alpha-dihydroartemisinin Unclear Artemether [1]
MR000301 Artemether Deoxyartemsinin Unclear Artemether [1]
MR000298 Artemether Dihydroartemisinin Oxidation - Oxidation Artemether [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008682 Dihydroqinghaosu (DQHS) Deoxydihydro-artemisinin Unclear - Unclear Arteether [3]
MR000315 2,3-dikeogulonic acid Deoxydihydro-artemisinin Unclear Ascorbic acid [4]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR008683 Deoxydihydro-artemisinin Arteether Metabolite M1 Oxidation - Hydroxylation Arteether [3]
References
1 DrugBank(Pharmacology-Metabolism)Artemether
2 Use of a physiologically-based pharmacokinetic model to simulate artemether dose adjustment for overcoming the drug-drug interaction with efavirenz In Silico Pharmacol. 2013 Mar 1;1:4. doi: 10.1186/2193-9616-1-4.
3 Synthesis, characterization, and antimalarial activity of the glucuronides of the hydroxylated metabolites of arteether
4 Ascorbic acid intake and oxalate synthesis Urolithiasis. 2016 Aug;44(4):289-97. doi: 10.1007/s00240-016-0868-7.

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