Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009220)
Formula
SVG example
Unclear
Reactant Carebastine Product Ebastine Metabolite M-3
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 4F2 (CYP4F2) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009219 Hydroxy-ebastine Carebastine Unclear - Unclear Ebastine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009221 Carebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009224 Ebastine Metabolite M-4 Ebastine Metabolite M-3 Unclear - Unclear Ebastine [3]
References
1 Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys
2 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.
3 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry

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