Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009221)
Formula
SVG example
N-dealkylation
Reactant Carebastine Product Deslakylebastine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009219 Hydroxy-ebastine Carebastine Unclear - Unclear Ebastine [1], [2]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009220 Carebastine Ebastine Metabolite M-3 Unclear - Unclear Ebastine [3], [4]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009229 Ebastine Deslakylebastine Oxidation - N-dealkylation Ebastine [3]
MR003703 LAS-X-113 Desalkylebastine Oxidation - N-Dealkylation LAS-X-113 [2]
References
1 Comparative pharmacokinetics of the histamine H1-receptor antagonist ebastine and its active metabolite carebastine in rats, guinea pigs, dogs and monkeys
2 Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metab Dispos. 2006 Nov;34(11):1793-7.
3 Involvement of CYP2J2 and CYP4F12 in the metabolism of ebastine in human intestinal microsomes
4 Identification of rat faecal metabolites of ebastine by B/E linked scanning liquid secondary ion mass spectrometry

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