Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009267)
Formula
CYP3A4 ...
SVG example
Monohydroxylation
Reactant LAROPIPRANT Product LAROPIPRANT Metabolite M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Metabolic Type Oxidation - Monohydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009265 LAROPIPRANT LAROPIPRANT Metabolite M2 Conjugation - Acyl glucuronide conjugation LAROPIPRANT [1]
MR009263 LAROPIPRANT LAROPIPRANT Metabolite M3 Unclear - Unclear LAROPIPRANT [1]
MR009269 LAROPIPRANT LAROPIPRANT Metabolite M4 Oxidation - Monohydroxylation LAROPIPRANT [1]
MR009271 LAROPIPRANT LAROPIPRANT Metabolite M5 Oxidation - N-dealkylation LAROPIPRANT [1]
MR009272 LAROPIPRANT LAROPIPRANT Metabolite M7 Oxidation - Oxidization LAROPIPRANT [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009268 LAROPIPRANT Metabolite M1 LAROPIPRANT Metabolite M9 Unclear - Unclear LAROPIPRANT [2]
References
1 Metabolism of MK-0524, a prostaglandin D2 receptor 1 antagonist, in microsomes and hepatocytes from preclinical species and humans
2 Absorption, metabolism, and excretion of [(14)C]MK-0524, a prostaglandin D(2) receptor antagonist, in humans

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