Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009504)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Ranolazine Product CVT-2551
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009508 Ranolazine CVT-2512 Conjugation - O-arylation Ranolazine [1]
MR009507 Ranolazine CVT-2513 Oxidation - N-dealkylation Ranolazine [1]
MR009500 Ranolazine CVT-2534 Oxidation - N-dealkylation Ranolazine [1]
MR009502 Ranolazine CVT-2535 Oxidation - N-dealkylation Ranolazine [1]
MR009506 Ranolazine CVT-2738 Oxidation - N-dealkylation Ranolazine [1], [2]
MR009509 Ranolazine CVT-3369 Hydrolysis - Hydrolysis Ranolazine [1]
MR009498 Ranolazine RS-88390 (CVT-2514) Oxidation - O-demethylation Ranolazine [1], [3]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009505 CVT-2551 CVT-3248 Oxidation - N-dealkylation Ranolazine [1]
References
1 Ranolazine for the treatment of chronic angina and potential use in other cardiovascular conditions
2 Comparison of pharmacokinetic parameters of ranolazine between diabetic and non-diabetic rats
3 Fatal, Intentional Overdose of Ranolazine: Post-Mortem Distribution of Parent Drug and its Major Metabolite

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