Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009592)
Formula
CYP2C8 ...
SVG example
N-demethylation
Reactant Rosuvastatin Product N-Desmethylrosuvastatin
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009593 Rosuvastatin Rosuvastatin 5S-lactone Oxidation - N-dealkylation Rosuvastatin [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Simultaneous Determination of Rosuvastatin, Rosuvastatin-5?S-lactone, and N-desmethyl Rosuvastatin in Human Plasma by UPLC-MS/MS and Its Application to Clinical Study

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