Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009593)
Formula
SVG example
N-dealkylation
Reactant Rosuvastatin Product Rosuvastatin 5S-lactone
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2C8 (CYP2C8) DME Info
Metabolic Type Oxidation - N-dealkylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009592 Rosuvastatin N-Desmethylrosuvastatin Oxidation - N-demethylation Rosuvastatin [1], [2]
References
1 Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675.
2 Simultaneous Determination of Rosuvastatin, Rosuvastatin-5?S-lactone, and N-desmethyl Rosuvastatin in Human Plasma by UPLC-MS/MS and Its Application to Clinical Study

If you find any error in data or bug in web service, please kindly report it to Dr. Yin and Dr. Li.