Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009784)
Formula
CYP3A4 ...
SVG example
Demethylation
Reactant Alvespimycin hydrochloride Product 17-DMAG M4
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009782 Alvespimycin hydrochloride 17-DMAG M1 Oxidation - Hydroxylation Alvespimycin hydrochloride [1]
MR009779 Alvespimycin hydrochloride 17-DMAG M2 Oxidation - Hydroxylation Alvespimycin hydrochloride [1]
MR009783 Alvespimycin hydrochloride 17-DMAG M3 Oxidation - Demethylation Alvespimycin hydrochloride [1]
References
1 In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes

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