Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009782)
Formula
CYP3A4 ...
SVG example
Hydroxylation
Reactant Alvespimycin hydrochloride Product 17-DMAG M1
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009779 Alvespimycin hydrochloride 17-DMAG M2 Oxidation - Hydroxylation Alvespimycin hydrochloride [1]
MR009783 Alvespimycin hydrochloride 17-DMAG M3 Oxidation - Demethylation Alvespimycin hydrochloride [1]
MR009784 Alvespimycin hydrochloride 17-DMAG M4 Oxidation - Demethylation Alvespimycin hydrochloride [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009795 AST-1306 Allitinib M14 Unclear - Unclear AST-1306 [2]
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009796 Allitinib M14 Allitinib M16 Unclear - Unclear AST-1306 [2]
References
1 In vitro metabolism of 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin in human liver microsomes
2 Metabolism and pharmacokinetics of allitinib in cancer patients: the roles of cytochrome P450s and epoxide hydrolase in its biotransformation

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