Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009849)
Formula
CYP3A4 ...
SVG example
Oxidation
Reactant Ambrisentan Product 4-hydroxymethyl?ambrisentan
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Metabolic Type Oxidation - Oxidation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009851 Ambrisentan Ambrisentan glucuronide Conjugation - Glucuronidation Ambrisentan [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009850 4-hydroxymethyl?ambrisentan 4-hydroxymethyl?ambrisentan glucuronide Unclear - Unclear Ambrisentan [2]
References
1 Effect of ketoconazole on the pharmacokinetic profile of ambrisentan. J Clin Pharmacol. 2009 Jun;49(6):719-24.
2 Clinical pharmacokinetics and drug-drug interactions of endothelin receptor antagonists in pulmonary arterial hypertension. J Clin Pharmacol. 2012 Dec;52(12):1784-805.

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