Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009902)
Formula
SVG example
Unclear
Reactant 6-mercaptopurine Product 6-methylmercaptopurine
Reactant Info Product Info
Metabolic Enzyme Thiopurine methyltransferase (TPMT) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009897 Azathioprine 6-mercaptopurine Unclear - Non-enzymaticreduction Azathioprine [1]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009898 6-mercaptopurine 6-thioinosine-monophosphate Unclear - Unclear Azathioprine [1]
MR009903 6-mercaptopurine 6-thioxanthine Unclear - Unclear Azathioprine [1]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009981 Mercaptopurine 6-methylmercaptopurine Unclear - Unclear Mercaptopurine [2], [3]
References
1 Gut Microbiota Metabolism of Azathioprine: A New Hallmark for Personalized Drug-Targeted Therapy of Chronic Inflammatory Bowel Disease
2 Azathioprine and 6-mercaptopurine pharmacogenetics and metabolite monitoring in inflammatory bowel disease
3 6-Mercaptopurine metabolism in Crohn's disease: correlation with efficacy and toxicity

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