Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009999)
Formula
CYP
SVG example
N-Demethylization
Reactant EDDP Product EMDP
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 (CYP) DME Info
Metabolic Type Oxidation - N-Demethylization
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009998 Methadone EDDP Oxidation - N-demethylation Methadone [1], [2]
References
1 Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991.
2 Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics

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