Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR009998)
Formula
CYP1A2 ...
SVG example
N-demethylation
Reactant Methadone Product EDDP
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 1A2 (CYP1A2) DME Info
Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 2C8 (CYP2C8) DME Info
Cytochrome P450 2C9 (CYP2C9) DME Info
Cytochrome P450 2C18 (CYP2C18) DME Info
Mephenytoin 4-hydroxylase (CYP2C19) DME Info
Cytochrome P450 2D6 (CYP2D6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Cytochrome P450 3A5 (CYP3A5) DME Info
Cytochrome P450 3A7 (CYP3A7) DME Info
Metabolic Type Oxidation - N-demethylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009993 Methadone 4-dimethylamino-22-diphenylvaleric acid Unclear - Unclear Methadone [1], [2]
MR009996 Methadone Methadol Unclear - Unclear Methadone [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR009999 EDDP EMDP Oxidation - N-Demethylization Methadone [1], [2]
References
1 Methadone metabolism and drug-drug interactions: in vitro and in vivo literature review. J Pharm Sci. 2018 Dec;107(12):2983-2991.
2 Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics

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