Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010000)
Formula
SVG example
Unclear
Reactant Methamphetamine hydrochloride Product Amphetamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2D6 (CYP2D6) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010007 Methamphetamine hydrochloride p-hydroxymethamphetamine Unclear - Unclear Methamphetamine hydrochloride [1], [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005723 Benzphetamine Amphetamine Unclear Benzphetamine [3]
MR004247 Etilamfetamine Amphetamine Unclear Etilamfetamine [4]
MR007177 Famprofazone Amphetamine Oxidation - N-dealkylation Famprofazone [5]
MR006298 Fenethylline Fenethylline Metabolite M-1(AP ) Unclear Fenethylline [6]
MR009984 Metamfetamine Amphetamine Unclear - Unclear Metamfetamine [7], [8], [1]
MR010844 Desmethyl selegiline Amphetamine Unclear - Unclear Selegiline [9]
MR007170 Methamphetamine Amphetamine Oxidation - N-demethylation Famprofazone [5]
MR010842 Methamphetamine Amphetamine Unclear - Unclear Selegiline [9]
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Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006299 Fenethylline Metabolite M-1(AP ) Fenethylline Metabolite M-5( p-hydroxy-AP) Unclear Fenethylline [6]
References
1 Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence
2 Effects of methamphetamine and its primary human metabolite, p-hydroxymethamphetamine, on the development of the Australian blowfly Calliphora stygia
3 DrugBank(Pharmacology-Metabolism):Benzphetamine
4 The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.
5 Identification of new urinary metabolites of famprofazone in humans
6 Metabolic fate of fenetylline in rat and man
7 Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
8 Drugs of abuse in a non-conventional sample; detection of methamphetamine and its main metabolite, amphetamine in abusers' clothes by HPLC with UV and fluorescence detection
9 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations

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