Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010844)
Formula
CYP2B6 ...
SVG example
Unclear
Reactant Desmethyl selegiline Product Amphetamine
Reactant Info Product Info
Metabolic Enzyme Cytochrome P450 2B6 (CYP2B6) DME Info
Cytochrome P450 3A4 (CYP3A4) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Produce The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010843 Selegiline Desmethyl selegiline Unclear - Unclear Selegiline [1]
MR002889 Selegiline hydrochloride Desmethylselegiline Oxidation - N-Dealkylation Selegiline hydrochloride [2], [3]
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR002892 Desmethylselegiline Levamfetamine Unclear Selegiline hydrochloride [2]
Other MR(s) Related to The Product of This MR
Other MR(s) That Produce The Product of This MR
MR ID Reactant Product MR Type Related Drug REF
MR005723 Benzphetamine Amphetamine Unclear Benzphetamine [4]
MR004247 Etilamfetamine Amphetamine Unclear Etilamfetamine [5]
MR007177 Famprofazone Amphetamine Oxidation - N-dealkylation Famprofazone [6]
MR006298 Fenethylline Fenethylline Metabolite M-1(AP ) Unclear Fenethylline [7]
MR009984 Metamfetamine Amphetamine Unclear - Unclear Metamfetamine [8], [9], [10]
MR010000 Methamphetamine hydrochloride Amphetamine Unclear - Unclear Methamphetamine hydrochloride [8], [9], [10]
MR007170 Methamphetamine Amphetamine Oxidation - N-demethylation Famprofazone [6]
MR010842 Methamphetamine Amphetamine Unclear - Unclear Selegiline [1]
⏷ Show the Full List of MR
Other MR(s) That Metabolize The Produtc of This MR
MR ID Reactant Product MR Type Related Drug REF
MR006299 Fenethylline Metabolite M-1(AP ) Fenethylline Metabolite M-5( p-hydroxy-AP) Unclear Fenethylline [7]
References
1 Physiologically Based Pharmacokinetic Modeling of Transdermal Selegiline and Its Metabolites for the Evaluation of Disposition Differences between Healthy and Special Populations
2 Comparative studies on the cytochrome p450-associated metabolism and interaction potential of selegiline between human liver-derived in vitro systems. Drug Metab Dispos. 2003 Sep;31(9):1093-102.
3 Detection of l-Methamphetamine and l-Amphetamine as Selegiline Metabolites. J Anal Toxicol. 2021 Feb 6;45(1):99-104. doi: 10.1093/jat/bkaa058.
4 DrugBank(Pharmacology-Metabolism):Benzphetamine
5 The influence of diuretics on the excretion and metabolism of doping agents. III. Etilamfetamine. Arzneimittelforschung. 1986 Sep;36(9):1413-6.
6 Identification of new urinary metabolites of famprofazone in humans
7 Metabolic fate of fenetylline in rat and man
8 Sex- and dose-dependency in the pharmacokinetics and pharmacodynamics of (+)-methamphetamine and its metabolite (+)-amphetamine in rats
9 Drugs of abuse in a non-conventional sample; detection of methamphetamine and its main metabolite, amphetamine in abusers' clothes by HPLC with UV and fluorescence detection
10 Reduced CYP2D6 activity is a negative risk factor for methamphetamine dependence

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