Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010009)
Formula
SVG example
Hydroxylation
Reactant Methotrexate Product MTX-7-OH
Reactant Info Product Info
Metabolic Type Oxidation - Hydroxylation
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010011 Methotrexate 2, 4-diamino-N(10)-methylpteroic acid (DAMPA) Unclear - Unclear Methotrexate [1]
MR010010 Methotrexate Methotrexate?polyglutamates Unclear - Unclear Methotrexate [2], [3]
References
1 Pharmacokinetics and metabolism of the methotrexate metabolite 2, 4-diamino-N(10)-methylpteroic acid
2 Measuring methotrexate polyglutamates
3 Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms

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