Details of the Metabolic Reaction (MR) | INTEDE

General Information of This Metabolic Reaction (MR) (ID: MR010011)
Formula	Unclear
	Reactant	Methotrexate		Product	2, 4-diamino-N(10)-methylpteroic acid (DAMPA)
	Reactant	Reactant Info		Product	Product Info
Metabolic Type	Unclear - Unclear

Other MR(s) Related to The Reactant of This MR

Other MR(s) That Metabolize The Reactant of This MR

MR ID	Reactant	Product	MR Type	Related Drug	REF
MR010010	Methotrexate	Methotrexate?polyglutamates	Unclear - Unclear	Methotrexate	[1], [2]
MR010009	Methotrexate	MTX-7-OH	Oxidation - Hydroxylation	Methotrexate	[3], [4]

References
1	Measuring methotrexate polyglutamates
2	Hepatotoxic potentials of methotrexate: Understanding the possible toxicological molecular mechanisms
3	Clinical and Laboratory Associations with Methotrexate Metabolism Gene Polymorphisms in Rheumatoid Arthritis
4	Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor Activation

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