Details of the Metabolic Reaction (MR)

General Information of This Metabolic Reaction (MR) (ID: MR010010)
Formula Reactant Methotrexate Product Methotrexate?polyglutamates
Reactant Info Product Info
Metabolic Enzyme Folylpolyglutamate synthase (FPGS) DME Info
Metabolic Type Unclear - Unclear
Other MR(s) Related to The Reactant of This MR
Other MR(s) That Metabolize The Reactant of This MR
MR ID Reactant Product MR Type Related Drug REF
MR010011 Methotrexate 2, 4-diamino-N(10)-methylpteroic acid (DAMPA) Unclear - Unclear Methotrexate [1]
MR010009 Methotrexate MTX-7-OH Oxidation - Hydroxylation Methotrexate [2], [3]
References
1 Pharmacokinetics and metabolism of the methotrexate metabolite 2, 4-diamino-N(10)-methylpteroic acid
2 Clinical and Laboratory Associations with Methotrexate Metabolism Gene Polymorphisms in Rheumatoid Arthritis
3 Leflunomide Increases Hepatic Exposure to Methotrexate and Its Metabolite by Differentially Regulating Multidrug Resistance-Associated Protein Mrp2/3/4 Transporters via Peroxisome Proliferator-Activated Receptor Activation

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